SP600125

SP600125

10 mg

Cat. No.: 60-S25

$65.00

SP600125 is a selective, reversible ATP competitive inhibitor of c-Jun N-terminal kinase (JNK). It exhibits greater than 300-fold selectivity for JNK against related MAP kinases ERK1 and p38-2, and the serine threonine kinase PKA. In cells, SP600125 causes dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocks the activation and differentiation of primary human CD4 cell cultures.

 

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Details

TECHNICAL INFORMATION

Other Names: Anthra[1-9-cd]pyrazol-6(2H)-one

Chemical Formula:  C14H8N2O

CAS Number: 129-56-6

Molecular Weight: 220.23

Purity:  >99%

Appearance: yellow powder

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble to 100mM in DMSO. Note: for most cells, the maximum tolerance to DMSO is <0.5%. If a precipitate is observed, vortex for 5 minutes.

 

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