ZSTK474

50 mg

Cat. No.: 86-M73

$99.00

ZSTK474 is a cell permeable and reversible P13K inhibitor with an IC₅₀ at 6nm. It was identified as part of a screening library, selected for its ability to block tumor cell growth. ZSTK474 has shown strong antitumor activities against human cancer xenographs when administered orally to mice without a significant toxic effect.

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TECHNICAL INFORMATION

Other Names: ZSTK-474

Chemical Formula:  C19H21F2N7O2

CAS Number: 475110-96-4

Molecular Weight: 417.41

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 20 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%. 

References

Yaguchi et al. (2006) Antitumor activity of ZSTK474 | a new phosphatidylinositol 3-kinase inhibitor. J Natl Cancer Inst. 98(8):545-56.

Kong et al. (2009) Antiangiogenic effect of ZSTK474 | a novel phosphatidylinositol 3-kinase inhibitor. Eur J Cancer. 45(5):857-65.

Dan et al. (2011) ZSTK474 | a specific phosphatidylinositol 3-kinase inhibitor | induces G1 arrest of the cell cycle in vivo. Eur J Cancer. Nov 14. Epub ahead of print.

Rewcastle et al. (2011) Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4 | 6-di(4-morpholinyl)-1 | 3 | 5-triazin-2-yl]-1H-benzimidazole (ZSTK474). J Med Chem. 54(20): 7105-26.

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