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Y27632

Name: Y27632
SKU: 53-B85
Price: 89.00 USD
Availability: InStock

2 mg

Cat. No.: 53-B85

Original price was: $109.00.Current price is: $89.00.

Y27632 (dihydrochloride) is a highly potent ATP-competitive inhibitor of Rho– associated coiled-coil forming protein serine/threonine kinase (ROCK). It has been shown to prevent dissociation-induced apoptosis in human embryonic stem cells (hES cells). Y27632 enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.

Categories: Small Molecules, Stem Cell

Details

TECHNICAL INFORMATION

Other Names: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride

Chemical Formula: C₁₄H₂₁N₃O· 2HCl

CAS Number: 146986-50-7

Molecular Weight: 320.3

Purity: >98% by HPLC

Appearance: White crystalline solid

Solubility: DMSO

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

PRODUCT USE

Soluble in DMSO. For a 10mM stock solution of Y27632, reconstitute the compound by adding 624μl of DMSO to the entire contents of the vial. Incubate in a 37°C water bath for 5 minutes if precipitate is observed. For most cells, the maximum tolerance to DMSO is <0.5%.