XAV939

5 mg

Cat. No.: 52-A47

$99.00

XAV939 is a cell permeable, small molecule inhibitor of the Wnt/β– catenin pathway. It inhibits tankyrase 1 (IC₅₀= 11nM)and tankyrase 2 (IC₅₀=4nM), stabilizes axin and stimulates β-catenin degradation.  Small molecule XAV939 has also been shown to inhibit proliferation of the µ-catenin-dependent colon carcinoma cell line DLD-1.

 

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TECHNICAL INFORMATION

 Other Names: 3,​5,​7,​8-​tetrahydro-​2-​[4-​(trifluoromethyl)phenyl]-​4H-​thiopyrano[4,​3-​d]pyrimidin-​4-​one

Chemical Formula: C14H11F3N2OS

CAS Number: 284028-89-3

Molecular Weight: 312.3

Purity:  >98%

Appearance: Crystalline solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO (50mM). For most cells, the maximum tolerance to DMSO is <0.5%.   

References

Huang et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling. Nature. 461(7264): 614-20.

Wang et al. (2011) Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β- catenin signaling. ACS Chem Bio. 6(2):192-7.

Karlberg et al. (2010) Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor. J Med Chem. 53(14)5352-5.

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