Vandetanib

50 mg

Cat. No.: 29-E58

$99.00

Vandetanib is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor. It has been shown to inhibit VEGFR-dependent tumor angiogenesis and EGFR– and RET-dependent tumor cell proliferation and survival.  Vandetanib has also been shown to inhibt fms-like tyrosine kinase 4  (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases. 

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TECHNICAL INFORMATION

Other Names: Caprelsa, Zactima, ZD6474

Chemical Formula:  C22H24BrFN4O2

CAS Number: 443913-73-3

Molecular Weight: 475.35

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 30 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%. 

References

Wedge et al. (2002) ZD6474 inhibits vascular endothelial growth factor signaling | angiogenesis | and tumor growth following oral administration. Cancer Res. 62(16):4645-55.

Yoshikawa et al. (2009) Vandetanib (ZD6474) | an inhibitor of VEGFR and EGFR signalling | as a novel molecular-targeted therapy against cholangiocarcinoma. Br J Cancer. 100(8):1257-66.

Sarkar et al. (2010) ZD6474 | a dual tyrosine kinase inhibitor of EGFR and VEGFR-2 | inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer Biol Ther. 9(8):592-603.

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