Triciribine

Triciribine

1 mg

Cat. No.: 32-M26

$109.00

Triciribine is a synthetic cell-permeable and reversible tricyclic nucleoside that selectively inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3 but does not inhibit Akt kinase activity or upstream Akt activators, PI3-Kinase or PDK1. It has shown to inhitib cell growth and induce apoptosis in cancer cells with aberrant Akt activity both in vitro and in vivo.

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TECHNICAL INFORMATION

Other Names1,​5-​dihydro-​5-​methyl-​1-​β-​D-​ribofuranosyl-​1,​2,​5,​6,​8-​pentaazaacenaphthylen-​3-​amine

Chemical Formula: C13H16N6O4

CAS Number: 35943-35-2

Molecular Weight: 320.3

Purity:  >98%

Appearance: crystalline solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at -4°C and protected from light.

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at >25mg/ml.

References

Yang | et al. (2004) Akt/protein kinase B signaling inhibitor-2 | a selective molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res. 64(13):4394-9.

Gloesenkamp et al. (2011) Akt inhibition by triciribine alone or as combination therapy for growth control of gastroenterpancreatic neuroendrocrine tumors. Int J Oncol. 40(3):876-88.

Evangelisti | et al. (2011) Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia. J Cell Physiol. 226(3):822-31.

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