SU6656

5mg

Cat. No.: 42-K78

$99.00

SU6656 is a potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Src kinases are known to function in signal transduction pathways. It inhibits Src as well as other closely related kinases including Fyn, Yes, and Lyn. It can act as a weak inhibitor of Lck and PDGF receptor kinase.

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Details

TECHNICAL INFORMATION

Other Names: 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide

Chemical Formula: C19H21N3O3S

CAS Number: 330161-87-0

Molecular Weight: 371.5

Purity: >98%

IC50= Src: 280nM, Fyn: 170nM, Yes: 20nM, Lyn: 130nM, Lck: 130nM, PDGF: >10µM

Appearance: Orange Crystalline Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 12mg/ml

References

Lannutti | B. | et al (2005). Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656. Blood. 105:3875-3878.

Blake | R. | et al (2000). Su6656 | a selective Src family kinase inhibitor | used to probe growth factor signaling. Mol. Cell. Biol. 20:9018-9027.

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