SU5402

SU5402

1 mg

Cat. No.: 79-E23

$184.00

SU5402 is a reversible, cell-permeable ATP competitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGF1) and a potent inhibitor of vascular endothelial growth factor receptor (VEGFR). It is a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit the phosphorylation of the insulin receptor. SU5402 has been shown to exhibit potent anticancer activity in vitro and in vivo.

 

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TECHNICAL INFORMATION

Other Names: 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone

Chemical Formula: C17H16N2O3

CAS Number: 215543-92-3

Molecular Weight: 296.32

Purity: ≥95% by HPLC

Appearance: White Solid

Solubility: DMSO to 100mM

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble to 100mM in 1eq. NaOH and to 100mM in DMSO. Note, for most cells, the maximum tolerance to DMSO is <0.5%.

References

Mohammadi et al. (1997). Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors. Science. 276 (5314): 955-960.

Grand et al. (2004). Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074. Leukemia. 18: 962-966.

Kiyonari et al. (2010). Three inhibitors of FGF receptor | ERK | and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability. Genesis.48 (5)317-27.

Nichols et al. (2009). Suppression of Erk signaling promotes ground state pluripotency in the mouse embryo. Development. 136 (19):3215-22.

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