SB431542

5 mg

Cat. No.: 21-A94

$84.00

SB431542 is a selective and potent inhibitor of TGFβ superfamily type I activin receptor-like kinase (ALK) receptor, specifically ALK4, ALK5 and ALK7. It does not affect BMP receptors ALK2, ALK3 or ALK6. SB431542 specifically blocks Smad signaling and suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes differentiation. When used in combination with MEK inhibitor PD0325901, SB431542 has been found to enhance reprogramming efficiency.

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TECHNICAL INFORMATION

Other Names: 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide

Chemical Formula: C22H16N4O3

CAS Number: 301836-41-9

Molecular Weight: 384.39

Purity:  ≥98%

Appearance: A crystalline solid

Solubility: DMSO, Ethanol

Working Concentration: 2µM

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO (20mg/ml). Soluble in ethanol (2mg/ml). Incubate in a 37°C water bath for 5 minutes if precipitate is observed.

References

Lin T. et al. (2009) A chemical platform for improved induction of human iPSCs. Nature Meth. 6: 805-808.

Inman G et al. (2002). SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4 | ALK5 | and ALK7. Mol Pharmacol 62(1):65-74.

Laping N et al. (2002). Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol. 62(1):58-64.

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