Nutlin-3

2 mg

Cat. No.: 75-D58

$69.00

Nutlin-3 is a MDM2 antagonist, a p53 activator and an apoptosis inducer. MDM2 works by binding the p53 tumor suppressor protein and negatively regulating its transcriptional activity and stability. Inhibition of the MDM-p53 interaction results in the stabilization of p53, cell cycle arrest and apoptosis.

Categories: Cancer, Small Molecules

Details

TECHNICAL INFORMATION

Other Names: (±)-4-[4,5-bis-(4-chlorophenyl)-2-(2- isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]- piperazin-2-one

Chemical Formula: C₃₀H₃₀Cl₂N₄O₄

CAS Number: 548472-68-0

PubChem Substance ID: 24724554

Molecular Weight: 581.5

Purity: >98%

Appearance: Crystalline solid

Solubility: DMSO

IC₅₀ : 0.09µM

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml. Incubate in a 37°C water bath for 5 minutes if precipitate is observed.

References

Vassiliv et al. (2004). In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 303:844-848.

Wakatsuki et al. (2003). Mechanics of cell spreading: role of myosin II. J Cell Sci. 116:1617-1625.

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Product Specifications

You're viewing: Nutlin-3

2 mg

Cat. No.: 75-D58

$69.00