Nutlin-3
Nutlin-3 - Image 2

Nutlin-3

2 mg

Cat. No.: 75-D58

$69.00

Nutlin-3 is a MDM2 antagonist, a p53 activator and an apoptosis inducer. MDM2 works by binding the p53 tumor suppressor protein and negatively regulating its transcriptional activity and stability. Inhibition of the MDM-p53 interaction results in the stabilization of p53, cell cycle arrest and apoptosis.

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Details

TECHNICAL INFORMATION

Other Names: (±)-​4-​[4,​5-​bis-​(4-​chlorophenyl)-​2-​(2-​ isopropoxy-​4-​methoxy-​phenyl)-​4,​5-​dihydro-​imidazole-​1-​carbonyl]- ​piperazin-​2-​one

Chemical Formula: C30H30Cl2N4O4

CAS Number: 548472-68-0

PubChem Substance ID: 24724554

Molecular Weight: 581.5

Purity:  >98%

Appearance: Crystalline solid

Solubility: DMSO

IC50 : 0.09µM

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C.

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml. Incubate in a 37°C water bath for 5 minutes if precipitate is observed.

References

Vassiliv et al. (2004). In vivo activation  of the p53 pathway by small-molecule antagonists of MDM2. Science. 303:844-848.

Wakatsuki et al. (2003). Mechanics of cell spreading: role of myosin II. J Cell Sci. 116:1617-1625.

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