MS-275

Name: MS-275
SKU: 92-Y43
Availability: InStock

10 mg

Cat. No.: 92-Y43

$69.00

MS-275 is a potent HDAC inhibitor with an IC50 of 0.3 and 8µM for HDAC1 and HDAC3. It has been shown to inhibit tumor growth by inducing tumor suppressors p21WAF1/CIP1 and gelsolin through the acetylation of histones and changing cell cycle distribution. MS-275 has been shown to exert dose-dependent effects in human leukemia cells at low concentrations in human prostate cancer lines. MS-275 inhibits proliferation of various human tumor cell lines and inhibits the growth of human tumor xenographs in the nude mouse.

Categories: Cancer, Small Molecules

Details

TECHNICAL INFORMATION

Other Names: MS-27-275, MS 275-27, Histone Deacetylase Inhibitor I, SNDX-275, Entinostat

Chemical Formula: C₂₁H₂₀N₄O₃

CAS Number: 209783-80-2

Molecular Weight: 376.41

Purity: >98%

Appearance: a crystalline solid

Solubility: DMSO

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

PRODUCT USE

Soluble in DMSO at 25 mg/ml with slight warming. If precipitate is observed, vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.