MG132

MG132

5mg

Cat. No.: 15-G73

$60.00

MG132 is a proteasome inhibitor. Proteasome are found at high concentrations in eukaryotic cells, which causes protein degradation. This inhibitor enhances thermotolerance in a variety of cell types. MG132 also activates JNK-1 which may lead to apoptosis under cell stress. It has been shown to be involved with the cell cycle, in controlling inflammatory processes and gene expression.

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Details

TECHNICAL INFORMATION

Other Names:N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(ls)-l-formyl-3-methylbutyl]-L-leucinamide

Chemical Formula: C26H41N3O5

CAS Number: 133407-82-6

Molecular Weight: 475.6

Purity:  >98%

Appearance: crystalline solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at -20°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at >95mg/ml. Incubate in a 37°C water bath for 5 minutes if precipitate is observed.

References

miR-122 regulates p53/Akt signaling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma

The proteasome inhibitor for MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and necksquamous cell carcinoma cells

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