LY294002

Name: LY294002
SKU: 89-Y31
Availability: InStock

5 mg

Cat. No.: 89-Y31

$79.00

LY294002 is a cell permeable, selective phosphatidylinositol 3-kinase (P13K) inhibitor that acts as a competitor inhibitor of the ATP binding site of the enzyme. LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In mESC’s LY294002 prevents self-renewal by inhibiting LIF2. LY294002 does not affect the activities of EGF receptor kinase, MAP kinase, PKC, PI 4-kinase, S6 kinase and c-Src even at 50µl. LY294002 has also been shown to be an inhibitor of casein kinase II.

Categories: Small Molecules, Stem Cell

Details

TECHNICAL INFORMATION

Other Names: 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

Chemical Formula: C₁₉H₁₇NO₃

CAS Number: 154447-36-6

Molecular Weight: 307.3

Purity: >98%

Appearance: Off White Crystalline solid

Solubility: DMSO

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

PRODUCT USE

Soluble in DMSO. For a 10mM concentrated stock solution, reconstitute the compound by adding 1627µl to the entire contents of the vial. If precipitate is observed, vortex for 5 minutes. For most cells the maximum tolerance to DMSO is <0.5%.