Indolactam V

Indolactam V

1mg

Cat. No.: 56-L54

$299.00

Indolactam V is an activator of protein kinase C (PKC) that works by inhibiting PKC isozymes (alpha, beta-I, beta-II, gamma, delta, epsilon, eta, theta). This inducing differentiation in embryonic stem cells into pancreatic progenitors. It also exhibits tumor promoting activity.

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TECHNICAL INFORMATION

Other Names: (2S, 5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one

Chemical Formula: C17H23N3O2

CAS Number: 90365-57-4

Molecular Weight: 301.4

Purity: >99%

IC50= 250nM

Appearance: Off White Crystalline Powder

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 10mM

References

Thatava | T. | et al (2011). Indolactam V/GLP-1 mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther. 18:283-93.

Xu | Z. | et al (2011). Total synthesis of (-)-indolactam V. Org Biomol Chem. 7:2512-7.

Bronner | S.M. | et al (2011). Overturning indolyne regioselectivities and synthesis of indolactam V. J Am Chem Soc. 133:3832-5.

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