Honokiol

Honokiol

10mg

Cat. No.: 37-R66

$109.00

Honokiol is a biologically active constituent of oriental medicinal herb Magnolia officinalis/grandiflora. It displays anxiolytic, antithrombotic, anti-tumor properties.  In addition it modulates the NF-κB activation pathway, an upstream effector VEGF, COX-2, and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides.

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Details

TECHNICAL INFORMATION

Other Names: 5,3’-Diallyl-2,4’-dihydroxydipehenyl, VEGFR tyrosine kinase inhibitor XIX, VEGFR2 kinase inhibitor XV

Chemical Formula: C18H18O2

CAS Number: 35354-74-6

Molecular Weight: 266.3

Purity: >98%

IC50= 0.5 & 11 nM

Appearance: White Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO.

References

Guillermo | R.F. | et al (2012). Time and dose-response effects of Honokiol on UVB-induced skin cancer development. Drug Disco Ther. 6:140-6.

Cheng | N. | et al (2011). Synergistic antitumor effects of liposomal Honokiol combined with cisplatin in colon cancer models. Oncol Lett. 2:957-962.

Choi | S.S. | et al (2012). Honokiol and magnolol stimulate glucose uptake by activating P13K-dependent Akt in L6 myotubes. Biofactors. 1872-8081.

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