GW788388

GW788388

5mg

Cat. No.: 38-X30

$90.00

GW788388 is a selective inhibitor of transforming growth factor-beta type I (TGF-betaI) receptor (activin receptor-like kinase 5 (ALK5)). It is know to inhibit esophageal squamous cell carcinoma induced neoangiogenisis.

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Details

TECHNICAL INFORMATION

Other Names: 4-(4-(3-(pyridine-2-yl)-1H-pyrazol-4-yl)-N-(tetranydro-2H-pyran-4-yl)benzamide

Chemical Formula: C25H23N5O2

CAS Number: 452342-67-5

Molecular Weight: 425.48

Purity: >99%

IC50= ALK5: 18nM

Appearance: White-Tan Powder

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 33mg/ml

References

De Oliveira | F.L. | et al (2012). Oral administration of GW788388 | an inhibitor of transforming growth factor beta signaling | prevents heart fibrosis in chagas disease. PLos Negl Trop Dis. 6:1696.

Petersen | M. | et al (2008). Oral administration of GW788388 | an inhibitor of TGF-beta type I and II receptor kinases | decreases renal fibrosis. Kidney Int. 73:705-15.

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