Ciglitazone

5mg

Cat. No.: 48-A90

$90.00

Ciglitazone is an antihyperglycemic agent of the thiazolidinedione structural class, selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). It activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo. Ciglitazone inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells.

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TECHNICAL INFORMATION

Other Names: 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-2, 4-thiazolidinedione

Chemical Formula: C18H23NO3S

CAS Number: 74772-77-3

Molecular Weight: 333.50

Purity: >98%

IC50= 3 µM

Appearance: Crystalline Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 25mg/ml

References

Lee | M.W. | et al (2012). Cell death is induced by Ciglitazone | a peroxisome proliferator-activated receptor _ (PPAR_) agonist | independently of PPAR_ in human glima cells. Biochem Biophys Res Commun. 417:552-7.

Yokoyama | Y. | et al (2011). Combination of Ciglitazone | a peroxisome proliferator-activated receptor gamma ligand | and cisplatin enhances the inhibition of growth of human ovarian cancer. J Cancer Res Clin Oncol. 137:1219-28.

Lai | L.j. | et al (2011). Pigment epithelial-derived factor inhibits c-FLIP expression and assists Ciglitazone-induced apoptosis in hepatocellular carcinoma. Anticancer Res. 31:1173-80.

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