CI-994

CI-994

10 mg

Cat. No.: 46-F92

$75.00

CI-994 is a histone deacetylase (HDAC) inhibitor that induces hyperacetylation in living cells.  CI-994 mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo.  CI-994 originally was developed as an anticonvulsant agent and later was reported to have antitumor activity.

 

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TECHNICAL INFORMATION

Other Names: Acetyldinaline, Goe 5549, Gö 5549. PD 123654, Tacedinaline

Chemical Formula:  C15H15N3O2

CAS Number: 112522-64-2

Molecular Weight: 269.30

Purity:  >98%

Appearance:  a crystalline solid 

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 66 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

References

Kraker et al. (2003) Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Mol Cancer Ther. 2(4):401-8.

Graziano et al. (2001) Induction of Apoptosis in Rat Peripheral Blood Lymphocytes by the Anticancer Drug CI-994 (Acetyldinaline)(*). J Biomed Biotechnol. 1(2):52-61.

Loprevite et al. (2005) In vitro study of CI-994 | a histone deacetylase inhibitor | in non-small cell lung cancer cell lines. Oncol Res. 15(1):29-48.

Hubeek et al. (2008) CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo. Oncol Rep. 19(6):1517-23.

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