BX-795

2 mg

Cat. No.: 68-J23

$84.00

BX-795 is a potent inhibitor of both PDK1 and TBK1 as well as IKKε.  It acts by blocking phosphorylation and is reversible.

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Details

TECHNICAL INFORMATION

Other Names: N-[3-[[5-IODO-4-[[3[[(2-Thienycarbonyl)Amino]Propyl]Amino]-2-Pyrimidinyl]Amino]Phenyl]-1-Pyrrolidinecarboxamide

Chemical Formula: C23H26IN7O2S

CAS Number: 702675-74-9

Molecular Weight: 591.47

Purity: >95%

IC50= 6.0 nM

Appearance: White Solid

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO (100mM). Incubate overnight

References

Clark | K. | et al. (2009) Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J Biol Chem. 284(21)14134-46.

Tamguney | T. | et al. (2008) Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Exp Cell Res. 314(11-12)2299-312.

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