BIX01294

Name: BIX01294
SKU: 74-O89
Availability: InStock

5 mg

Cat. No.: 74-O89

$99.00

BIX01294 is a histone lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. It selectively inhibits the G9a HMTase and the generation of histone H3 lysine 9 methylation. BIX01294, when used in combination with HDAC inhibitor Valproic Acid has been used as a replacement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes. BIX01294 is a useful for the study of histone lysine methylation, differentiation and reprogramming.

Categories: Small Molecules, Stem Cell

Details

TECHNICAL INFORMATION

Other Names: 2-(Hexahydro-4-methyl-1H-1,4-diazep
in-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piper
idinyl]-4-quinazolinamine trihydrochloride

Chemical Formula: C₂₈H₃₈N₆O₂.3HCl

CAS Number: 935693-62-2

Molecular Weight: 600.02

Purity: >99%

Appearance: white solid

Solubility: DMSO

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

PRODUCT USE

Soluble in DMSO. For a 10mM concentrated stock solution, reconstitute the compound in 1.02ml of DMSO to the entire contents of the vial. If precipitate is observed, vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.