BIBW-2992

Name: BIBW-2992
SKU: 72-C33
Availability: InStock

5 mg

Cat. No.: 72-C33

$89.00

BIBW-2992 is a irreversible and dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) kinases. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed IC₅₀ values of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly selective for these kinases and no additional inhibition of other kinases has been observed. BIBW-2992 has also been shown to suppress EGF-induced EGFR phosphorylation and cellular proliferation in various cell lines.

Categories: Cancer, Small Molecules

Details

TECHNICAL INFORMATION

Other Names: Afatinib

Chemical Formula: C₂₄H₂₅ClFN₅O₃

CAS Number: 850140-72-6

Molecular Weight: 485.94

Purity: >98%

Appearance: a crystalline solid

Solubility: DMSO

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store aliquots at -20°C.

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

PRODUCT USE

Soluble in DMSO at 200 mg/ml. Soluble in ethanol at 25mg/ml. If precipitate is observed, vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.