AT9283

2mg

Cat. No.: 64-Q25

$100.00

AT9283 is a multi-targeted kinase inhibitor of both Aurora kinases (A & B) as well as Janus kinase (Jak) 2. It also targets serine/threonine protein kinases associated with myeloid cell proliferation. AT9283 inhibited growth and survival of multiple solid tumor cell lines.

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Details

TECHNICAL INFORMATION

Other Names: 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea

Chemical Formula: C19H23N7O2

CAS Number: 896466-04-9

Molecular Weight: 381.43

Purity: >98%

IC50= Aurora A: 3nM, Aurora B: 3nM, JAK2: 1.2nM

Appearance: Powder

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 76mg/ml

References

Qi | W. | et al (2012). AT9283 | a novel aurora kinase inhibitor | suppresses tumor growth in aggressive B-cell lymphomas. Int. J. Cancer. 130:2997-3005.

Santo | L. | et al (2011). Antimyeloma activity of a multitargeted kinase inhibitor | AT9283 | via potent aurora kinase and Stat3 inhibition either alone or in combination with lenalidomide. Cin. Cancer Res. 17:3259-71.

Tanaka | R. | et al (2010). Activity of the multitargeted kinase inhibitor | AT9283 | in imatinib-resistant BCR-ABL-positive leukemic cell. Blood. 116:2089-95.

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