AT13387

5mg

Cat. No.: 81-D36

$280.00

AT13387 is a synthetic, small-molecule inhibitor of heat shock protein 90 (Hsp90). It selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.

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Details

TECHNICAL INFORMATION

Other Names: (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone

Chemical Formula: C24H31N3O3

CAS Number: 912999-49-6

Molecular Weight: 409.52

Purity: >99%

IC50= 18nM

Appearance: White Powder

Solubility: DMSO (100mM)

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO. Soluble at 20mg/ml

References

Smyth | T. | et al. (2012). The HSP90 Inhibitor | AT13387 | Is Effective against Imatinib-Sentitive and ?Resistant Gastrointestinal Stromal Tumor Models. Mol Cancer Ther.

Graham | B. | et al. (2012). The heat shock protein 90 inhibitor | AT13387 | displays a long duration of action in vitro and in vivo in non-small cell lung cancer. Cancer Sci. 103:522-7.

Kang | M.H. | et al. (2012). Initial testing (Stage 1) of At13387 | an HSP90 inhibitor | by the pediatric preclinical testing program. Pediatr Blood Testing. 59:185-8.

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