Stem Cell
Showing 25–45 of 45 results
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LY294002
LY294002 is a cell permeable, selective phosphatidylinositol 3-kinase (P13K) inhibitor that acts as a competitor inhibitor of the ATP binding site of the enzyme. LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In mESC’s LY294002 prevents self-renewal by inhibiting LIF2. LY294002 does not affect the activities of EGF receptor kinase, MAP kinase, PKC, PI 4-kinase, S6 kinase and c-Src even at 50µl. LY294002 has also been shown to be an inhibitor of casein kinase II.
5 mg
Cat. No.: 89-Y31
$79.00
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MG132
MG132 is a proteasome inhibitor. Proteasome are found at high concentrations in eukaryotic cells, which causes protein degradation. This inhibitor enhances thermotolerance in a variety of cell types. MG132 also activates JNK-1 which may lead to apoptosis under cell stress. It has been shown to be involved with the cell cycle, in controlling inflammatory processes and gene expression.
5mg
Cat. No.: 15-G73
$60.00
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PD0325901
PD0325901 is an organic molecule targeting mitogen– activated protein kinase (MAPK/ERK kinase or MEK). PD0325901 is a derivative of MEK inhibitor CI-1040 and selectively binds to and inhibits MEK which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. In combination with CHIR99021, PD0325901 has been shown to prevent cell differentiation and sustain ES cell self-renewal.
Sale!2 mg
Cat. No.: 39-C68
Original price was: $219.00.$89.00Current price is: $89.00.
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PD173074
PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR. It has been shown to arrest the G0/G1 phase of FGFR3– expressing cells. PD173074 blocks the FGFR signaling pathway and leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 has been shown to dramatically decrease their differentiation potential and clonogenicity.
2 mg
Cat. No.: 14-Z32
$79.00
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PP242
PP242 is a potent and selective inhibitor of mTOR, inhibitor, a Ser/Thr kinase and cell growth controller. PP242, but not Rapamycin has been shown to induce cell death in mouse and human leukemia cells in vitro. In vivo, PP242 delayed leukemia onset and enhanced the effects of the front-line tyrosine kinase inhibitors more effectively than rapamycin. PP242 has also been shown to significantly augment histone deacetylase inhibitor-induced apoptosis in hepatocellular carcinoma cells.
5 mg
Cat. No.: 26-Q09
$69.00
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PS48
PS48 is an allosteric small molecule activator of phosphoinositide-dependent protein kinase 1 (PDK1) that binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of the only allosteric compounds that targets a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlaps with the ATP binding site. PS48 has been shown to enhance reprogramming of neonatal human epidermal keratinocytes (NHEKs).
5 mg
Cat. No.: 16-M34
$69.00
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Purmorphamine
Purmorphamine is a 2,6,9-trisubstituted purine that has been shown to promote the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. Purmorphamine has been found to directly bind to and activate the 7-transmembrane Smo receptor of the Hedgehog signaling pathway. It has also been used in studies to replace sonic hedgehog for the generation of motor neurons from human embryonic stem cells.
5 mg
Cat. No.: 11-E93
$99.00
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Resveratrol
Resveratrol is a natural polyphelol, found in grapes and red wine, and is a selective inhibitor of cyclooxygenase-1 (COX-1). It inhibits COX and peroxidase activities of COX-1 with essentially no inhibition of the COX activity of COX-2. It has also been used extensively in stem cell studies to enhance self-renewal and multipotency of MSCs. It has anti-tumor, antioxidant, anti-platelet, anti-inflammatory and anti-fungal effects.
100mg
Cat. No.: 68-H42
$50.00
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Reversine
Reversine is a potent, selective A3 adenosine receptor antagonist. It has been shown to induce differentiated myogenic-linage committed cells to become multipotent mesenchymal progenitor cells.
2 mg
Cat. No.: 18-S41
$84.00
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RG108
RG108 is a potent and specific DNA methyltransferase (DNMT) inhibitor. It causes demethylation and reactivation of tumor suppressor genes and can be used to enhance reprogramming. RG108 has been found to inhibit human tumor cell line proliferation and increases doubling time in culture.
10 mg
Cat. No.: 41-L99
$99.00
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RO4929097
RO4929097 is a small molecule gamma secretase inhibitor with an IC₅₀ of 4nM. It binds to gamma secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.
2 mg
Cat. No.: 80-Y15
$169.00
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SB202190
SB202190 is a pyridinyl imidazole that inhibits p38 kinase in vivo through competition with ATP. It binds within the ATP pocket of the active kinase and selectively inhibits p38α and β isoforms. SB202190 induces apoptosis through the activation of cysteine protease (CPP32) like kinases. SB202190 has been shown to block both lipopolysaccharide (LPS) induced gene expression and nitric oxide (NO) induced stabilization of interleukin (IL) -8 mRNA in monocytes.
5 mg
Cat. No.: 42-F97
$59.00
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SB431542
SB431542 is a selective and potent inhibitor of TGFβ superfamily type I activin receptor-like kinase (ALK) receptor, specifically ALK4, ALK5 and ALK7. It does not affect BMP receptors ALK2, ALK3 or ALK6. SB431542 specifically blocks Smad signaling and suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes differentiation. When used in combination with MEK inhibitor PD0325901, SB431542 has been found to enhance reprogramming efficiency.
5 mg
Cat. No.: 21-A94
$84.00
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Sodium Butyrate
Sodium Butyrate is a short fatty acid chain that has an effect on the molecular, tissue and cellular levels. Sodium Butyrate has been shown to induce cell growth arrest, differentiation and apoptosis in cancer cells. It inhibits histone deacetylase (HDAC) and decreases Ca²⁺ release from intracellular stores. Sodium butyrate has been used to direct the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with Activin A.
5 g
Cat. No.: 71-B16
$29.00
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SP600125
SP600125 is a selective, reversible ATP competitive inhibitor of c-Jun N-terminal kinase (JNK). It exhibits greater than 300-fold selectivity for JNK against related MAP kinases ERK1 and p38-2, and the serine threonine kinase PKA. In cells, SP600125 causes dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocks the activation and differentiation of primary human CD4 cell cultures.
10 mg
Cat. No.: 60-S25
$65.00
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SU5402
SU5402 is a reversible, cell-permeable ATP competitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGF1) and a potent inhibitor of vascular endothelial growth factor receptor (VEGFR). It is a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit the phosphorylation of the insulin receptor. SU5402 has been shown to exhibit potent anticancer activity in vitro and in vivo.
1 mg
Cat. No.: 79-E23
$184.00
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Thiazovivin
Thiazovivin is a small molecule that has been shown to dramatically improve survival of hESCs upon trypsinization. When used in combination with ALK5 inhibitor SB431542 and MEK inhibitor PD0325091, Thiazovivin has been shown to enhance the efficiency of fibroblast reprogramming.
Sale!1 mg
Cat. No.: 40-W12
Original price was: $219.00.$159.00Current price is: $159.00.
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Tranylcypromine
Tranylcypromine hydrochloride , also known as 2-PCPA, is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110), a histone demethylase, and non-hydrazine monoamine oxidases (MAO). Histones contain unstructured N-terminal residues that are the site of numerous post-translational modifications, involving acetylation, ubiquitination, methylation, and sumoylation to produce a specific gene regulatory outcome. Complementary enzymes catalyze the addition and removal of these modifications as needed. The amine oxidase domain-containing enzyme lysine-specific demethylase 1 (LSD1) is a part of one of two classes of histone demethylases capable of demethylating lysine residues. LSD1 shares similar catalytic sites with monoamine oxidases (MAO) A and B. Treatment of P19 embryonal carcinoma cells with tranylcypromine resulted in global increase in H3K4 methylation as well as transcriptional derepression of the pluripotent stem cell marker Oct43.
50mg
Cat. No.: 65-L28
$25.00
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Valproic Acid
Valproic Acid is a small molecule histone deacetylase (HDAC) inhibitor that that exhibits anticancer, anti-inflammatory and neuroprotective effects . It has been shown to inhibit multiple pathways including the ERK, PKC and Wnt/β-Catenin pathways. Valproic Acid has been shown to regulate the differentiation and proliferation of various cell types, including mesenchymal and hematopoietic stem cells, primary neurons, neuroblastomas and neural progenitor cells. Valproic acid, when used in combination with cytokines differentiate cells into a uniform and homogeneous cell population of hepatic progenitor cells, followed by maturation into functional hepatocytes.
5 g
Cat. No.: 25-B43
$49.00
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XAV939
XAV939 is a cell permeable, small molecule inhibitor of the Wnt/β– catenin pathway. It inhibits tankyrase 1 (IC₅₀= 11nM)and tankyrase 2 (IC₅₀=4nM), stabilizes axin and stimulates β-catenin degradation. Small molecule XAV939 has also been shown to inhibit proliferation of the µ-catenin-dependent colon carcinoma cell line DLD-1.
5 mg
Cat. No.: 52-A47
$99.00
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Y27632
Y27632 (dihydrochloride) is a highly potent ATP-competitive inhibitor of Rho– associated coiled-coil forming protein serine/threonine kinase (ROCK). It has been shown to prevent dissociation-induced apoptosis in human embryonic stem cells (hES cells). Y27632 enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
Sale!2 mg
Cat. No.: 53-B85
Original price was: $109.00.$89.00Current price is: $89.00.
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Showing 25–45 of 45 results