Stem Cell
Showing 1–24 of 45 results
-
A-922500
A-922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor for both human and mouse. DGATs catalyze the final reaction step in the synthesis of triglyceride.
5 mg
Cat. No.: 44-K21
$150.00
Add to cart -
A769662
A769662 is a potent and reversible small molecule that activates AMP-activated protein kinase (AMPK). The activation of AMPK inhibits mTOR (mammalian target of rapamycin) signaling, which is a positive effector of cell growth, proliferation and survival. A769662 has been shown to inhibit the Na⁺K⁺-ATPase at higher concentrations. It also inhibits the differentiation of adipocytes.
10 mg
Cat. No.: 46-D13
$99.00
Add to cart -
A83-01
A83-01 is a TGFβ kinase/activin receptor like kinase (ALK5) inhibitor. It blocks the phosphorylation of Smad2 and inhibits TGFβ-induced epithelial-to-mesenchymal transition. A83-01 is more potent than small molecule SB431542, and has been shown to inhibit differentiation of rat induced pluripotent stem cells (iPSCs) and increases clonal expansion efficiency. Small molecule A83-01 helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.
2 mg
Cat. No.: 63-A05
$99.00
Add to cart -
Anacardic Acid
Anacardic acid is a histone acetyltransferase (HAT) inhibitor. It inhibits the HAT activity of the transcription co-activators p300 and p300/CREB-biding protein associated factor (pCAF) with IC50 values of 8.5 and 5 µM. It has been shown to display a variety of biological activities, including antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition. Anacardic acid has been shown to decrease expression of NF-κB regulated gene products including, invasion, inflammation, proliferation and cell survival. It has also been linked to be a potent activator of Aurora Kinase A (ARK-1) mediated phosphorylation of histone H3.
5 mg
Cat. No.: 08-N16
$89.00
Add to cart -
BIO
BIO is a potent, reversible and ATP-competitive inhibitor of GSK3α/β. The inhibition of GSK by BIO has been shown to activate the Wnt signaling pathway and sustain pluripotency in murine and human embryonic stem cells. BIO is the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. It has also been shown to induce the differentiation of neonatal cardiomyocytes.
2 mg
Cat. No.: 45-H38
$79.00
Add to cart -
BIX01294
BIX01294 is a histone lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. It selectively inhibits the G9a HMTase and the generation of histone H3 lysine 9 methylation. BIX01294, when used in combination with HDAC inhibitor Valproic Acid has been used as a replacement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes. BIX01294 is a useful for the study of histone lysine methylation, differentiation and reprogramming.
5 mg
Cat. No.: 74-O89
$99.00
Add to cart -
Brefeldin A
Brefeldin A (BFA) (IC50 value of 0.2 μM) is an inhibitor of ATPase.
ATPase is a chemical enzyme. It is essential in the ADP/ATP exchange providing chemical potential energy. ATP supplies the energy for such physiological activities such as importing metabolites necessary for cell metabolism, exporting toxins, wastes, and solutes that can hinder cellular processes, cell proliferation, ER stress and so forth.
When tested with cell line HEK293 cells (stably express wild-type (wt) CRELD2), BFA treatment nearly abolished the secretion of wtCRELD2 completely via inhibiting the transportation of proteins from the ER to the Golgi apparatus [4]. In MCF-7 cells and Hela cells, treatment with BFA induced p53 expression via inhibiting ATP which enhanced ER stress [5]. When treated with colorectal cancer cell line HCT116 cells, BFA treatment induced cells apoprosis by inhibiting ATP which functioned in the process of cellular vesicle trafficking
Treatment with BFA could attenuate stimulus-dependent hyperalgesia phenomenon via inhibiting vesicular exocytosis which process is important for ATP release.
BFA also is reported as an inhibitor for GTP/GDP exchange in a dose-dependent way, which is important in vesicular trafficking.
Cat. No.: 23-S79
$54.00
Add to cart -
BX-795
BX-795 is a potent inhibitor of both PDK1 and TBK1 as well as IKKε. It acts by blocking phosphorylation and is reversible.
2 mg
Cat. No.: 68-J23
$84.00
Add to cart -
CHIR99021
CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3β (GSK3β). CHIR99021 does not show cross-reactivity against cyclin-dependent kinases (CDKs) with a 350 fold selectivity toward GSK3β compared to CDKs with a Kᵢ of <10nM in vitro. CHIR99021 has been shown in long term expansion of murine embryonic stem cells in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402.
Sale!2 mg
Cat. No.: 27-H76
Original price was: $219.00.$89.00Current price is: $89.00.
Add to cart -
Ciglitazone
Ciglitazone is an antihyperglycemic agent of the thiazolidinedione structural class, selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). It activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo. Ciglitazone inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells.
5mg
Cat. No.: 48-A90
$90.00
Add to cart -
Cyclopamine
Cyclopamine is a small molecule inhibitor of the sonic hedgehog pathway (Hh) by binding to the heptahelical bundle of Smoothened. It inhibits the growth of medulloblastoma cells. Hedgehog signaling is involved in embryogenesis as well as cancer progression. It is a steroid alkaloid and originally identified as a teratogenic agent.
5 mg
Cat. No.: 29-O52
$199.00
Add to cart -
Daidzin
Daidzin is a glucoside of the isoflavone daidzein found in soy beans. It demonstrates chemopreventive activities by inhibiting the bioactivation of carcinogenic arylamines. It is also a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase.
1mg
Cat. No.: 30-Z35
$39.00
Add to cart -
DAPT
DAPT is a γ-secretase inhibitor that indirectly inhibits Notch, a γ-secretase substrate. Since Notch is involved in the development of the nervous system and pancreas, DAPT has been suggested to be used in the modulation of Notch activity in embryonic stem cell differentiation. As an inhibitor of γ-secretase, DAPT may also be useful in the study of β-amyloid (Aβ) formation.
5 mg
Cat. No.: 47-T13
$89.00
Add to cart -
Dexamethasone
Dexamethasone, a synthetic glucocorticoid with a higher affinity than a natural ligand, cortisol, has a range of effects on cell survival, cell signaling and gene expression. It is know to affect inflammatory responses, cellular proliferation, and differentiation in target tissues. Dexamethasone has been shown to inhibit differentiation of cord blood stem cell derived dendritic cells (DC) precusors into immature DCs.
100mg
Cat. No.: 58-I55
$35.00
Add to cart -
Dorsomorphin
Dorsomorphin (also known as Compound C) is a potent, reversible, AMPK inhibitor with Ki of 109 NM in the absence of AMP. In addition, it has been found to selectively inhibit bone morphogenetic protein (BMP) signaling.
Cat. No.: 08-D89
$99.00
Add to cart -
EHNA Hydrochloride
EHNA Hydrochloride is a reversible adenosine deaminase inhibitor that selectively inhibits the cGMP-specific phosphodieterase (PDE2). At a 10µM concentration, EHNA has been shown to effectively and reversibly block the differentiation and maintain the pluripotency of the hES cell line SA121 in feeder- free cultures without exogenously added FGF for up to 30 passages. EHNA has also been used to study the cardioprotective and neuroprotective efforts during ischemia and in the study of cAMP/cGMP signaling.
10 mg
Cat. No.: 23-F18
$69.00
Add to cart -
Forskolin
Forskolin is a cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Cyclic AMP is a signaling molecule and key regulator of critical enzymes in cellular processes. Forskolin has also been shown to effect calcium currents and inhibit MAP kinase.
10 mg
Cat. No.: 86-G99
$119.00
Add to cart -
G418
Geneticin Sulfate, also known as G418, is an aminoglycoside antibiotic. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that G418 inhibits the incorporation of amino acids into protein and can destroy fibroblasts. G418 is toxic to bacteria, yeast, higher plants, mammalian cells, protozoans and helminths. In mammalian cells, selection is commonly performed using 400 mg/L G418, followed by 200 mg/L for culture maintenance. G418 is commonly used for the selection of cells that are genetically engineered with a plasmid containing the neo (neor) gene, which provides resistance to G418. This antibiotic is commonly used during the selection of transfected cell lines.
250mg
Cat. No.: 38-T17
$39.00
Add to cart -
HA-1077 (dihydrochloride)
HA-1077 is a potent inhibitor of Rho-associated kinase II (ROCK-II), and also inhibits Protein Kinase C-related kinase 2 (PRK2), Mitogen- and Stress-Activated Protein Kinase (MSK1), and Mitogen Activated Protein Kinase-Activated Protein Kinase 1b (MAPKAP-K1b). HA-1077 is a novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist. Through the inhibition of Rho-kinase, HA-1077 has been shown to reduce blood vessel constriction, decrease pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in rodent models.
10 mg
Cat. No.: 61-F49
$99.00
Add to cart -
iCRT 14
Y27632 (dihydrochloride) is a highly potent ATP-competitive inhibitor of Rho– associated coiled-coil forming protein serine/threonine kinase (ROCK). It has been shown to prevent dissociation-induced apoptosis in human embryonic stem cells (hES cells). Y27632 enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
Cat. No.: 81-C19
$89.00
Add to cart -
Indolactam V
Indolactam V is an activator of protein kinase C (PKC) that works by inhibiting PKC isozymes (alpha, beta-I, beta-II, gamma, delta, epsilon, eta, theta). This inducing differentiation in embryonic stem cells into pancreatic progenitors. It also exhibits tumor promoting activity.
1mg
Cat. No.: 56-L54
$299.00
Add to cart -
IWP-2
IWP-2 is an inhibitor of Wnt production and an inactivator of Porcn function. The Wnt/b-catenin pathway maintains transcriptional programs that enable stem cells to remain multipotent and hyperactivation of this pathway leads to disease stage. IWP-2 inactivates Porcn function by either directly inhibiting the Porcn active site or by modulating the function of the Porcn regulator.
2 mg
Cat. No.: 57-G89
$99.00
Add to cart -
LDE225
LDE225 (NPV-LDE225) is a novel and specific small molecule Smoothened (Smo) inhibitor with an IC₅₀ of 11nM. LDE225 has been shown to potentially inhibit Hh- and Smo-dependent proliferation in vivo. It also induced the regression of preformed basaloid lesions with an IC50 of <150 nmol/l and almost complete regression at 1.5 μmol/l. Topical application of a 1% LDE225 solution to depilated skin of C57/BL6 mice completely inhibited hair growth during anagen phase as well as the expression of the Hh-pathway target genes and partial inhibition was obtained when applying a 0.3% solution.
2 mg
Cat. No.: 43-X52
$139.00
Add to cart -
LDN193189
LDN193189 is a highly potent small molecule BMP inhibitor. It inhibits BMP type I receptors ALK2, ALK3 and ALK6. LDN193189 was derived from structure-activity relationship studies of Dorsomorphin and functions by preventing phosphorylation of Smad1, Smad5 and Smad8. It shows in vivo clinical utility by reducing ectopic ossification in mouse models.
Sale!2 mg
Cat. No.: 36-F52
Original price was: $219.00.$119.00Current price is: $119.00.
Add to cart
Showing 1–24 of 45 results