Small Molecules
Showing 73–96 of 108 results
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PRE-084
PRE-084 is a high affinity sigma receptor agonist, selective for the σ1 subtype. It is a potent ligand of the σ receptor without much affinity for the PCP receptors.
10mg
Cat. No.: 06-R16
$82.00
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PS48
PS48 is an allosteric small molecule activator of phosphoinositide-dependent protein kinase 1 (PDK1) that binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of the only allosteric compounds that targets a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlaps with the ATP binding site. PS48 has been shown to enhance reprogramming of neonatal human epidermal keratinocytes (NHEKs).
5 mg
Cat. No.: 16-M34
$69.00
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Purmorphamine
Purmorphamine is a 2,6,9-trisubstituted purine that has been shown to promote the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. Purmorphamine has been found to directly bind to and activate the 7-transmembrane Smo receptor of the Hedgehog signaling pathway. It has also been used in studies to replace sonic hedgehog for the generation of motor neurons from human embryonic stem cells.
5 mg
Cat. No.: 11-E93
$99.00
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Rapamycin
Rapamycin is a macrocyclic triene antibiotic that binds to the cytosolic protein FK-binding protein 12 (FKBP12) and inhibits mTOR pathway by directly binding to the mTOR Complex1 (mTORC1). It is a potent immunosuppressant and has shown anticancer activity. Rapamycin It has a variety of uses both in vitro and in vivo and has been used to prevent organ rejection after transplantation.
Sale!5 mg
Cat. No.: 33-U72
Original price was: $129.00.$65.00Current price is: $65.00.
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Resveratrol
Resveratrol is a natural polyphelol, found in grapes and red wine, and is a selective inhibitor of cyclooxygenase-1 (COX-1). It inhibits COX and peroxidase activities of COX-1 with essentially no inhibition of the COX activity of COX-2. It has also been used extensively in stem cell studies to enhance self-renewal and multipotency of MSCs. It has anti-tumor, antioxidant, anti-platelet, anti-inflammatory and anti-fungal effects.
100mg
Cat. No.: 68-H42
$50.00
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Reversine
Reversine is a potent, selective A3 adenosine receptor antagonist. It has been shown to induce differentiated myogenic-linage committed cells to become multipotent mesenchymal progenitor cells.
2 mg
Cat. No.: 18-S41
$84.00
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RG108
RG108 is a potent and specific DNA methyltransferase (DNMT) inhibitor. It causes demethylation and reactivation of tumor suppressor genes and can be used to enhance reprogramming. RG108 has been found to inhibit human tumor cell line proliferation and increases doubling time in culture.
10 mg
Cat. No.: 41-L99
$99.00
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RO4929097
RO4929097 is a small molecule gamma secretase inhibitor with an IC₅₀ of 4nM. It binds to gamma secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.
2 mg
Cat. No.: 80-Y15
$169.00
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Roscovitine
Roscovitine, also known as Seliciclib or CYC202, is a potent and reversible inhibitor of select cyclin-dependent kinases (CDKs), CDK1, CDK2, and CDK5. It has less sensitivity towards related kinases including ERK1,2. This molecule competes for the binding site of ATP in the catalytic cleft. Treatment of cultured cells with roscovitine can cause cell cycle arrest or apoptosis.
1mg
Cat. No.: 34-K14
$29.00
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SAHA (Vorinostat)
SAHA (Vorinostat) is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme and blocks substrate access. It inhibits class I and class II HDACs at around 50nM. SAHA has been shown to cause growth arrest and death of some transformed cells both in vitro and in vivo, with little or no toxic effects on normal cells.
100 mg
Cat. No.: 31-V28
$99.00
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Saracatinib (AZD0530)
Saracatinib is a highly selective, orally available Src/Abl kinase inhibitor. It is highly selective for Src and Abl kinases against a large range of tyrosine and serine-threonine kinases (VEGFR, FGFR, c-Kit etc,) Saracatinib exerts its activity through ATP competitive and reversible inhibition of the target enzyme. Saracatinib has been shown to inhibit tumor growth in a manner independent of dose and inhibits phosphorylation of focal adhesion kinase (FAK) and paxillin in a dose-dependent manner in a Calu-6 Xenograft model.
10 mg
Cat. No.: 12-B11
$99.00
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SB202190
SB202190 is a pyridinyl imidazole that inhibits p38 kinase in vivo through competition with ATP. It binds within the ATP pocket of the active kinase and selectively inhibits p38α and β isoforms. SB202190 induces apoptosis through the activation of cysteine protease (CPP32) like kinases. SB202190 has been shown to block both lipopolysaccharide (LPS) induced gene expression and nitric oxide (NO) induced stabilization of interleukin (IL) -8 mRNA in monocytes.
5 mg
Cat. No.: 42-F97
$59.00
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SB431542
SB431542 is a selective and potent inhibitor of TGFβ superfamily type I activin receptor-like kinase (ALK) receptor, specifically ALK4, ALK5 and ALK7. It does not affect BMP receptors ALK2, ALK3 or ALK6. SB431542 specifically blocks Smad signaling and suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes differentiation. When used in combination with MEK inhibitor PD0325901, SB431542 has been found to enhance reprogramming efficiency.
5 mg
Cat. No.: 21-A94
$84.00
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Selumetinib
Selumetinib, also known as AZD6244, is a potent inhibitor of MAPK/ERK kinase 1/2. It is not competitive with ATP and inactivates the ERK1/2 phosphorylation. This is important because these kinases lie downstream to BFAF and RAGS genes. The effect of mutation in these genes is controlled by inhibiting the kinases downstream.
5mg
Cat. No.: 07-V75
$89.00
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Sodium Butyrate
Sodium Butyrate is a short fatty acid chain that has an effect on the molecular, tissue and cellular levels. Sodium Butyrate has been shown to induce cell growth arrest, differentiation and apoptosis in cancer cells. It inhibits histone deacetylase (HDAC) and decreases Ca²⁺ release from intracellular stores. Sodium butyrate has been used to direct the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with Activin A.
5 g
Cat. No.: 71-B16
$29.00
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Sorafenib
Sorafenib, also known as Nexavar, is a small molecule inhibitor of several tyrosine protein kinases, VEGFR 2 & 3 as well as PDGFR, and RAF/MEK/ERK cascade inhibitor. It also inhibits c-Kit, the ligand for Stem cell factor. It does not significantly inhibit MEK-1 or ERK-1 activity. It interacts in combination with the proteasome inhibitor bortezomib to induce apoptosis in a broad spectrum of neoplastic cell lines.
NOTE: The small molecule Sorafenib sold by Reagents Direct is NOT Nexavar®, and is NOT for human use.
5mg
Cat. No.: 13-D24
$99.00
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SP600125
SP600125 is a selective, reversible ATP competitive inhibitor of c-Jun N-terminal kinase (JNK). It exhibits greater than 300-fold selectivity for JNK against related MAP kinases ERK1 and p38-2, and the serine threonine kinase PKA. In cells, SP600125 causes dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocks the activation and differentiation of primary human CD4 cell cultures.
10 mg
Cat. No.: 60-S25
$65.00
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SU5402
SU5402 is a reversible, cell-permeable ATP competitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGF1) and a potent inhibitor of vascular endothelial growth factor receptor (VEGFR). It is a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit the phosphorylation of the insulin receptor. SU5402 has been shown to exhibit potent anticancer activity in vitro and in vivo.
1 mg
Cat. No.: 79-E23
$184.00
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SU6656
SU6656 is a potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Src kinases are known to function in signal transduction pathways. It inhibits Src as well as other closely related kinases including Fyn, Yes, and Lyn. It can act as a weak inhibitor of Lck and PDGF receptor kinase.
5mg
Cat. No.: 42-K78
$99.00
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TG101348
TG101348 is an ATP competitive Janus -associated kinase 2 (JAK2) inhibitor. It has has also been shown to inhibit Flt3 and Ret. It is not known to suppress any other kinases. It blocks the JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2V617F-expressing cell lines.
5mg
Cat. No.: 48-F21
$150.00
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Thiazovivin
Thiazovivin is a small molecule that has been shown to dramatically improve survival of hESCs upon trypsinization. When used in combination with ALK5 inhibitor SB431542 and MEK inhibitor PD0325091, Thiazovivin has been shown to enhance the efficiency of fibroblast reprogramming.
Sale!1 mg
Cat. No.: 40-W12
Original price was: $219.00.$159.00Current price is: $159.00.
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Tozasertib
Tozasertib is a potent inhibitor of all aurora kinases, including isotypes A, B and C. It has been shown to inhibit cell cycle progression, induce apoptosis and block tumor growth in varieties of in vivo xenograft models. Tozasertib has been shown to cause accumulation of cells with 4N DNA content and potently inhibit the proliferation of a wide variety of tumor cell types with IC50 values ranging from 15 to 113 nM. Tozasertib had no effect on the viability of noncycling primary human cells at concentrations as high as 10uM.
25 mg
Cat. No.: 11-W09
$59.00
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Tranylcypromine
Tranylcypromine hydrochloride , also known as 2-PCPA, is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110), a histone demethylase, and non-hydrazine monoamine oxidases (MAO). Histones contain unstructured N-terminal residues that are the site of numerous post-translational modifications, involving acetylation, ubiquitination, methylation, and sumoylation to produce a specific gene regulatory outcome. Complementary enzymes catalyze the addition and removal of these modifications as needed. The amine oxidase domain-containing enzyme lysine-specific demethylase 1 (LSD1) is a part of one of two classes of histone demethylases capable of demethylating lysine residues. LSD1 shares similar catalytic sites with monoamine oxidases (MAO) A and B. Treatment of P19 embryonal carcinoma cells with tranylcypromine resulted in global increase in H3K4 methylation as well as transcriptional derepression of the pluripotent stem cell marker Oct43.
50mg
Cat. No.: 65-L28
$25.00
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Trichostatin A (TSA)
Trichostatin A is a selective and potent inhibitor of histone deacetylase (HDAC). It selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, resulting in chromatin relaxation and modulation of gene expression. Trichostatin A has been shown to inhibit both the G1- and G2– phases of the mammalian cell cycle and has been used to induce apoptosis in cancer cells with low toxicity to non-cancer cells.
1 mg
Cat. No.: 62-K44
$79.00
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Showing 73–96 of 108 results