Small Molecules
Showing 25–48 of 108 results
-
Crizotinib
Crizotinib is a potent ATP competitive inhibitor of c-MET and anaplastic lymphoma kinase (ALK). It has been shown to display antitumor efficacy in multiple tumor models and has been shown to inhibit c-MET dependent proliferation, migration and invasion of tumor cells in vitro. Crizotinib is selective for c-MET and ALK against over 120 different kinases.
5 mg
Cat. No.: 61-V83
$129.00
Add to cart -
Cyclopamine
Cyclopamine is a small molecule inhibitor of the sonic hedgehog pathway (Hh) by binding to the heptahelical bundle of Smoothened. It inhibits the growth of medulloblastoma cells. Hedgehog signaling is involved in embryogenesis as well as cancer progression. It is a steroid alkaloid and originally identified as a teratogenic agent.
5 mg
Cat. No.: 29-O52
$199.00
Add to cart -
Dacomitinib
Dacomitinib, also known as PF-00299804, is a second-generation irreversible pan-erbB (HER) receptor tyrosine kinase inhibitor. It is believed to irreversibly inhibit erbB tyrosine kinase activity through binding at the ATP site and covalent modification of nucleophilic cysteine residues in the catalytic domains of erbB family members. The HER family of tyrosine kinases included receptors HER-1 (EGFR), HER-2,3 and 4. The HER signaling pathway plays a role in the normal regulation of cell growth and proliferation, differentiation, and apoptosis. Activation of HER receptors drives signal transduction pathways; dysregulated signaling through the HER receptors may lead to malignant transformation and growth.
5mg
Cat. No.: 21-Q15
$199.00
Add to cart -
Daidzin
Daidzin is a glucoside of the isoflavone daidzein found in soy beans. It demonstrates chemopreventive activities by inhibiting the bioactivation of carcinogenic arylamines. It is also a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase.
1mg
Cat. No.: 30-Z35
$39.00
Add to cart -
DAPT
DAPT is a γ-secretase inhibitor that indirectly inhibits Notch, a γ-secretase substrate. Since Notch is involved in the development of the nervous system and pancreas, DAPT has been suggested to be used in the modulation of Notch activity in embryonic stem cell differentiation. As an inhibitor of γ-secretase, DAPT may also be useful in the study of β-amyloid (Aβ) formation.
5 mg
Cat. No.: 47-T13
$89.00
Add to cart -
Dexamethasone
Dexamethasone, a synthetic glucocorticoid with a higher affinity than a natural ligand, cortisol, has a range of effects on cell survival, cell signaling and gene expression. It is know to affect inflammatory responses, cellular proliferation, and differentiation in target tissues. Dexamethasone has been shown to inhibit differentiation of cord blood stem cell derived dendritic cells (DC) precusors into immature DCs.
100mg
Cat. No.: 58-I55
$35.00
Add to cart -
Dorsomorphin
Dorsomorphin (also known as Compound C) is a potent, reversible, AMPK inhibitor with Ki of 109 NM in the absence of AMP. In addition, it has been found to selectively inhibit bone morphogenetic protein (BMP) signaling.
Cat. No.: 08-D89
$99.00
Add to cart -
Dovitinib
Dovitinib is a small molecule receptor tyrosine kinase inhibitor. It potently inhibits receptor tyrosine kinases including FLT3, c-KIT, CSF-1R/c-fms, FGFR1, FGFR3, VEGFR1/Flt1,VEGFR2/Flk1, VEGFR3/Flt4, PDGFRβ, and PDGFRα. Dovitinib shows both antitumor and antiangiogenic activities in vivo. It has also been used as an effective treatment in xenograft mouse models of FGFR3 multiple myeloma (MM).
10 mg
Cat. No.: 80-Z03
$99.00
Add to cart -
EHNA Hydrochloride
EHNA Hydrochloride is a reversible adenosine deaminase inhibitor that selectively inhibits the cGMP-specific phosphodieterase (PDE2). At a 10µM concentration, EHNA has been shown to effectively and reversibly block the differentiation and maintain the pluripotency of the hES cell line SA121 in feeder- free cultures without exogenously added FGF for up to 30 passages. EHNA has also been used to study the cardioprotective and neuroprotective efforts during ischemia and in the study of cAMP/cGMP signaling.
10 mg
Cat. No.: 23-F18
$69.00
Add to cart -
Enzastaurin
Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50’s of 0.006, 0.039, 0.083 and 0.110 µM, respectively. It has a direct effect on human tumor cells by inducing apoptosis and suppressing the proliferation of cultured tumor cells. Enzastaurin suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay and decreases microvessel density. It also prevents VEGF secretion from human tumor cell xenographs in nude mice. Prolonged courses of Enzastaurin increases chemotherapy or radiation tumor growth delay of breast, glioma and small cell lung cancer xenographs.
10 mg
Cat. No.: 19-P20
$99.00
Add to cart -
Everolimus
Everolimus inhibits mTOR (mammalian target of rapamycin), a serine-threonine kinase, by binding with high affinity to the FK506 binding protein-12 (FKBP-12) thus inducing cell growth arrest and apoptosis. It is chemically very similar to Rapamycin. It is also used to prevent rejection of organ transplants.
10 mg
Cat. No.: 55-X21
$114.00
Add to cart -
Fludarabine
Fludarabine, also known as Fludara, F-ara-A, and NSC 118218, is a purine antimetabolite. It’s activity occurs as the result of activation to 2-fluoro-ara-ATP and includes inhibition of DNA synthesis primarily in the S-phase of cell division by inhibition of ribonucleotide reductase and the DNA polymerases. It is also postulated that fludarabine interferes with RNA by decreased incorporation of uridine and leucine into RNA and protein, respectively. Fludarabine is also active against non-proliferating cells.
10mg
Cat. No.: 31-V88
$55.00
Add to cart -
Forskolin
Forskolin is a cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Cyclic AMP is a signaling molecule and key regulator of critical enzymes in cellular processes. Forskolin has also been shown to effect calcium currents and inhibit MAP kinase.
10 mg
Cat. No.: 86-G99
$119.00
Add to cart -
FTY720
FTY720 is a potent sphingosine-1-phosphate (S1P) receptors agonist that reverses the effects of BCR-ABL kinase. It is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5.) FTY720 is a novel immunomodulating agent that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.
5 mg
Cat. No.: 14-F83
$69.00
Add to cart -
G418
Geneticin Sulfate, also known as G418, is an aminoglycoside antibiotic. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that G418 inhibits the incorporation of amino acids into protein and can destroy fibroblasts. G418 is toxic to bacteria, yeast, higher plants, mammalian cells, protozoans and helminths. In mammalian cells, selection is commonly performed using 400 mg/L G418, followed by 200 mg/L for culture maintenance. G418 is commonly used for the selection of cells that are genetically engineered with a plasmid containing the neo (neor) gene, which provides resistance to G418. This antibiotic is commonly used during the selection of transfected cell lines.
250mg
Cat. No.: 38-T17
$39.00
Add to cart -
GANT 61
GANT 61 is a GLI antagonist. It inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GL1 nuclear accumulation. GANT 61 has been shown to inhibit proliferation of PANC1 and 22Rv1 cancer cells in vitro. In Vivo, it has displayed display antiproliferative effects and antitumor activity. GANT 61 has also been shown to block cell growth in vivo xenograft models using human prostate cancer cells.
5 mg
Cat. No.: 89-J92
$99.00
Add to cart -
GDC0449 (Vismodegib)
GDC0449 is a potent hedgehog (Hh) signaling pathway inhibitor with an IC₅₀ of 3nM. The Hedgehog signaling pathway plays an important role in tissue growth and repair. GDC0449 works by blocking the activities of the Hedgehog-ligand cell surface receptors PTCH or SMO and suppresses Hedgehog signaling. It has been shown to inhibit the growth of primary pancreatic xenographs without non-specifically inhibiting pancreatic cell proliferation in vitro. GDC0449 has also been shown to inhibit ABCG2, Pgp, and MRP1-important ABC transporters associated with MDR. It has also been used to treat medullablastoma in animal models.
5 mg
Cat. No.: 17-G94
$99.00
Add to cart -
GDC0941
GDC0941 is a phosphatidylinositol 3-kinase (P13K) inhibitor. GDC-0941 inhibits the activity of recombinant PI3K in vitro with IC50’s of 0.003 µM (P110α), 0.033 µM (P110β), 0.003 µM (P110δ), 0.075 µM (P110γ), 0.58 µM (mTOR) and 1.23 µM (DNA-PK).
5 mg
Cat. No.: 78-S14
$99.00
Add to cart -
Genistein
Genistein is a naturally occurring isoflavone found mainly in soy products. It inhibits protein tyrosine kinase and topoisomerase-II as well as angiogenesis. It has been shown to be involved in regulating apoptosis, an important target in cancer research.
10 mg
Cat. No.: 94-W43
$44.00
Add to cart -
GW788388
GW788388 is a selective inhibitor of transforming growth factor-beta type I (TGF-betaI) receptor (activin receptor-like kinase 5 (ALK5)). It is know to inhibit esophageal squamous cell carcinoma induced neoangiogenisis.
5mg
Cat. No.: 38-X30
$90.00
Add to cart -
HA-1077 (dihydrochloride)
HA-1077 is a potent inhibitor of Rho-associated kinase II (ROCK-II), and also inhibits Protein Kinase C-related kinase 2 (PRK2), Mitogen- and Stress-Activated Protein Kinase (MSK1), and Mitogen Activated Protein Kinase-Activated Protein Kinase 1b (MAPKAP-K1b). HA-1077 is a novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist. Through the inhibition of Rho-kinase, HA-1077 has been shown to reduce blood vessel constriction, decrease pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in rodent models.
10 mg
Cat. No.: 61-F49
$99.00
Add to cart -
Honokiol
Honokiol is a biologically active constituent of oriental medicinal herb Magnolia officinalis/grandiflora. It displays anxiolytic, antithrombotic, anti-tumor properties. In addition it modulates the NF-κB activation pathway, an upstream effector VEGF, COX-2, and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides.
10mg
Cat. No.: 37-R66
$109.00
Add to cart -
iCRT 14
Y27632 (dihydrochloride) is a highly potent ATP-competitive inhibitor of Rho– associated coiled-coil forming protein serine/threonine kinase (ROCK). It has been shown to prevent dissociation-induced apoptosis in human embryonic stem cells (hES cells). Y27632 enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
Cat. No.: 81-C19
$89.00
Add to cart -
INCB-018424
INCB-018424, also known as Ruxolitinib, is a potent and selective inhibitor of Janus -associated kinase 1 and 2 (JAK1,2). It acts by blocking the JAK/STAT pathway. It is also shown to selectively inhibit a wide range of other kinases including JAK3.
5 mg
Cat. No.: 28-R52
$150.00
Add to cart
Showing 25–48 of 108 results