PRE-084

10mg

Cat. No.: 06-R16

$82.00

PRE-084 is a high affinity sigma receptor agonist, selective for the σ1 subtype. It is a potent ligand of the σ receptor without much affinity for the PCP receptors.

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Details

TECHNICAL INFORMATION

Other Names: 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate hydrochloride

Chemical Formula: C19H27NO3–HCL

CAS Number: 138847-85-5

Molecular Weight: 353.9

Purity: >99%

IC50= 6nM

Appearance: White Solid

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO.

References

Griesmaier | E. | et al (2012). Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice. Exp neurol. 237:388-95.

Allahtavakoli | M. | et al (2011). Sigma-1 receptor ligand PRE-084 reduced infarct volume | neurological deficits | pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats. Brain res bull. 85:219-24.

Skuza | G. | et al (2009). Antidepressant-like effect of PRE-084 | a selective sigma1 receptor agonist | in Albino Swiss and C57BL/6J mice. Pharmacol Rep. 61:1179-83.

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