GANT 61

5 mg

Cat. No.: 89-J92

$99.00

GANT 61 is a GLI antagonist. It inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GL1 nuclear accumulation. GANT 61 has been shown to inhibit proliferation of PANC1 and 22Rv1 cancer cells in vitro. In Vivo, it has displayed display antiproliferative effects and antitumor activity. GANT 61 has also been shown to block cell growth in vivo xenograft models using human prostate cancer cells.

 

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TECHNICAL INFORMATION

Other Names: NSC 136476, 2,​2′-​[[dihydro-​2-​(4-​pyridinyl)-​1,​3(2H,​4H)-​pyrimidinediyl]bis(methylene)]bis(N,​N-​dimethyl-​benzenamine)

Chemical Formula: C27H35N5

CAS Number: 500579-04-4

Molecular Weight: 429.6

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 5mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%.

References

Hyman et al. (2009) Small molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. PNAS. 105(33):14132-7.

Mazumdar et al. (2011) Blocking Hedgehog survival signaling at the level of the GL1 genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res. 71(17):5904-14.

Desch et al. (2010) Inhibition of GLI | but not Smoothened | induces apoptosis in chronic lymphocytic leukemia cells. Oncogene. 29(35):4885-95.

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