FTY720

FTY720

5 mg

Cat. No.: 14-F83

$69.00

FTY720 is a potent sphingosine-1-phosphate (S1P) receptors agonist that reverses the effects of BCR-ABL kinase.  It is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5.) FTY720 is a novel immunomodulating agent that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.

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TECHNICAL INFORMATION

Other Names: Fingolimod, Gilenia

Chemical Formula: C19H33NO2 · HCl

CAS Number: 162359-56-0

Molecular Weight: 343.9

Purity:  >98%

Appearance:  a crystalline solid  

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble in DMSO at 100 mg/ml. If precipitate is observed,  vortex for 5 minutes. For most cells, the maximum tolerance to DMSO is less than 0.5%. 

References

Chiba et al. (2006) Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol Immunol. 3(1):11-9.

Zheng et al. (2010) PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. J Cell Biochem. 111(1):218-28.

Liu et al. (2010) FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma. Clin Cancer Res. 16(12):3182-92.

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