SP600125

10 mg

Cat. No.: 60-S25

$65.00

SP600125 is a selective, reversible ATP competitive inhibitor of c-Jun N-terminal kinase (JNK). It exhibits greater than 300-fold selectivity for JNK against related MAP kinases ERK1 and p38-2, and the serine threonine kinase PKA. In cells, SP600125 causes dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocks the activation and differentiation of primary human CD4 cell cultures.

 

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TECHNICAL INFORMATION

Other Names: Anthra[1-9-cd]pyrazol-6(2H)-one

Chemical Formula:  C14H8N2O

CAS Number: 129-56-6

Molecular Weight: 220.23

Purity:  >99%

Appearance: yellow powder

Solubility: DMSO

 

STORAGE AND HANDLING

Storage: Store at 4°C and protected from light. Following reconstitution, store  aliquots at -20°C. 

Stability: Stock solutions stable at -20°C for up to 2 years.

Shipping Conditions: Shipped at room temperature.

 

PRODUCT USE

Soluble to 100mM in DMSO. Note: for most cells, the maximum tolerance to DMSO is <0.5%. If a precipitate is observed, vortex for 5 minutes.

 

References

Bennett et al. (2001) SP600125 | an anthrapyrazolone inhibitor of Jun N-terminal kinase. PNAS. 98(24):13681-6.

Assi et al. (2006) The specific JNK inhibitor SP600125 targets tumour necrosis factor-α production and epithelial cell apoptosis in acute marine colitis. Immunology. 118(1):112-121.

Nakava et al. (2009) A JNM inhibitor SP600125 induces defective cytokinesis and enlargement in P19 embryonal carcinoma cells. Cell Biochem Funct. 27(7):468.72.

Renlund et al. (2008) c-Jun N-terminal Kinase Inhibitor II (SP600125) activates mullerian inhibiting substance type II receptor-mediated signal transduction. Endocrinology. 149(1): 108-115.

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